Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 13th International Conference on Neurology and Neurosurgery Paris, France.

Day 2 :

Keynote Forum

Guy Hugues Fontaine

Universite Pierre et Marie Curie, France

Keynote: First Case of Brain Protection in Out of Hospital Cardiac Arrest
OMICS International Neurosurgery 2017 International Conference Keynote Speaker Guy Hugues Fontaine photo
Biography:

Abstract:

My wife Ilfat, a 73 year-old psychiatrist, experienced OHCA on June 2011 in the living room where she was watching the BBC world channel on TV. She suddenly stopped talking. I waited a few moments before turning towards her to check whether she might have fallen asleep. To my horror I found that she was cyanotic, her head drooped on her chest. It was obvious that she had signs of possible sudden cardiac arrest. I immediately laid her down on the floor. There was no femoral pulse. I initiated standard CPR including chest compression (90 compressions/minute) for about 30 seconds followed by mouth to mouth breathing. I then resumed cardiac massage since she did not regain consciousness and there was no femoral pulse. I had a defibrillator in the basement of my house because of my interest in the Fulguration procedure. Although the defibrillator was more than 30 years old I knew that this machine would work by electrical current from the outlet. The defibrillator was charged to allow for a first shock and a second shock to be delivered through metallic disk–shaped electrodes that were on this old machine.  Her body jumped but the shocks were ineffective. Since I had no gel to apply between the electrodes and the skin to decrease the impedance, I applied saliva to the electrodes and then gave a third shock.  This last shock was successful, and the femoral pulse returned strong and regular. Recurrent chest compression produced the characteristic sound make by a broken chondro-costal joint. The femoral pulse remained stable, regular and strong.  I estimated that about 5 to 6 minutes elapsed between her loss of consciousness and the return to a stable circulation. Since there was no sign of return to consciousness and she had bilateral pupillary dilation, I then addressed the issue of possible brain protection. Fortunately, I had a smaller portable bottle now called the “Fontaine bottle” (JACC 2016) that was designed with a gas regulator to be used with a nasal cannula inserted into the nose to provide protection of the brain by nasal cooling.

Because of the invasive insertion in fossa nasalis, Ilfat exhibited a pain reaction which I interpreted as a positive sign for her chances of survival. When the injector was in position I opened the valve of the cylinder and induced nasal cooling by expansion of the CO2. Her hospital course was notable for repeated episodes of ventricular fibrillation with the same ECG pattern of Torsade de Pointes-like tachycardia degenerating in Ventricular Fibrillation in a few seconds. The absence of Troponin release demonstrated that she had no acute myocardial infarction which was my main concern. When sedation was stopped, she was fully awake and the tracheal tube was removed.  Ilfat first question was whether she was treated with nasal cooling!  She refused amiodarone but was treated with bisoprolol which proved effective. After recovery from the implantation of a dual chamber defibrillator she had only thoracic pain which was a direct consequence of chest compression. This pain disappeared in two months. Psychological test showed that she had absolutely no neurologic deficit. In particular, she could remember 9 telephone numbers. During the follow-up, she experienced three more episodes of sudden death with drop (one with injury of the face) immediately converted by the defibrillator leading to an increase of Bisoprolol. However, she experienced a total obstruction of the trunk cerebral artery in November 2015 also treated in La Salpêtrière by thrombolysis and clot extraction 1:20 after the loss of consciousness. She again recovered with absolutely no neurological deficit except a slower rate of speaking. She is now treated by Eliquis and enjoy normal life and continue to see her patients. Thanks to advanced techniques of resuscitation techniques and clinical electrophysiology (my area of expertise) as well as interventional neurology 

Keynote Forum

Radu Mutihac

University of Bucharest, Romania

Keynote: Functional Neuroimaging Data Mining
OMICS International Neurosurgery 2017 International Conference Keynote Speaker Radu Mutihac photo
Biography:

Radu Mutihac is a Head of Medical Physics Section, works in Neuroscience, Signal Processing, Microelectronics and Artifi cial Intelligence. As a Post-doc/Research Associate/Visiting Professor/Full Professor, he does his research at University of Bucharest, International Centre for Theoretical Physics (Italy), Ecole Polytechnique (France), Institute Henri Poincare (France) and KU Leuven (Belgium). His research in “Fused biomedical imaging modalities” was carried out at Johns Hopkins University, National Institutes of Health and Walter Reed Army Institute of Research, USA. He is a member of ISMRM, ESMRMB, OHBM, Romanian US Alumni Association, and Fellow of Signal Processing and Neural Networks Society IEEE. He has published over 100 scientifi c papers, 12 monographs and contributed with chapters in other 10 text books. He contributed to more than 150 scientifi c meetings with posters and oral presentations, seminars, invited and plenary lectures, as well as acting as Organizer, Chairman, and Keynote Speaker.

Abstract:

Imaging Neuroscience is aiming to reveal functional changes in brain activity and structural changes in neuroanatomy. Biomedical time series, particularly functional brain imaging data, are rich sources of information about physiological processes, but they are often contaminated with artifacts and noise, and typically recorded as mixtures of unknown combinations of sources summing up differently in time and/or space. In many cases, even the nature of sources is an open question. The interest in functional brain studies lays in the electrical activity of fi ring neurons, which cannot entirely be inferred by analyzing the vascular process because the hemodynamic lag varies in a complex way from tissue to tissue, and no theory on the relationship between the electrical and hemodynamic processes is available. Most of imaging Neuroscience relies on confi rmatory data analysis (CDA) like inferential hypothesis-led analysis, which makes use of spatially extended processes (e.g., statistical parametric mapping - SPM). Yet spatiotemporal characteristics of brain activity are frequently unknown and variable, which preclude their evaluation by confi rmatory methods only. Revealing unanticipated or missed patterns of activation, data mining (DM) and exploratory data analysis (EDA) allow to improve or even to change the original hypotheses. In contrast to CDA, exploratory methods entail no reference to prior knowledge of the structure in data and provides models whose characteristics are determined by the statistical properties of data only and no statistical model is required on the inferences to perform. However, some differences exist: while DM searches for consistent patterns and predictability, EDA looks for systematic relationships between variables. The contribution : In imaging Neuroscience, the dynamic interplay between hypothesis generation and hypothesis testing, a Hegelian synthesis of EDA and CDA, has the best chance of dealing successfully with the increasingly complex experiments, or the emerging broad range of theoretical and clinical studies. As such, confi rmatory and exploratory analyses appear more complementary rather than competitive.